The N45S is a compound with a very high initial bite. It is a good step up from N35S and has an exceptional response. The brake power itself is also elevated so the difference between initial bite and maximum brake power is lower than N35S. The driver only needs about 15 bar of initial brake pressure to create a very good deceleration and even at very high speed the driver still only needs to apply a fairly low amount of pedal pressure. The modulation is still good and controllable, and gives a good brake balance. The compound is suitable for high-speed race cars with a very good traction and down force, but has also shown itself to be usable to achieve extreme braking power in WRC Rally cars.

Even in wet conditions it has a great pedal feel, and it lets the driver keep a good rhythm of driving. The very high initial bite enables the driver to stay shorter periods of time on the pedal, which is also a good way to reduce disc temperatures. The N45S is like the other compounds, gentle to the discs, has a low wear and does not create heat cracks or other disc problems.